NDLI: DMSO/I2 mediated C-C bond cleavage of α-ketoaldehydes followed by C-O bond formation: a metal-free approach for one-pot esterification.

Content Provider	Semantic Scholar
Author	Venkateswarlu, Vunnam Kumar, K. A. Aravinda Gupta, Sorav Singh, Deepika Vishwakarma, Ram A. Sawant, Sanghapal D.
Copyright Year	2015
Abstract	A novel and efficient I2/DMSO mediated metal-free strategy is presented for the direct C-C bond cleavage of aryl-/heteroaryl- or aliphatic α-ketoaldehydes by C2-decarbonylation and C1-carbonyl oxidation to give the corresponding carboxylic acids followed by esterification in one pot, offering excellent yields in both the steps. Here, DMSO acts as the oxygen source/oxidant and this reaction works very well under both conventional heating and microwave irradiation. This is a very simple and convenient protocol.
File Format	PDF HTM / HTML
DOI	10.1039/c5ob01015b
PubMed reference number	26110656
Journal	Medline
Volume Number	13
Issue Number	29
Alternate Webpage(s)	http://www.rsc.org/suppdata/c5/ob/c5ob01015b/c5ob01015b1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c5ob01015b
Journal	Organic & biomolecular chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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