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Graft-versus-host disease after allogeneic hematopoietic stem cell transplantation induces a CD8+ T cell-mediated graft-versus-tumor effect that is independent of the recognition of alloantigenic tumor targets.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stelljes, Matthias Strothotte, Robert Pauels, Hans-Gerd Poremba, Christopher Milse, Michaela Specht, Christiane Albring, Jörn Bisping, Guido Scheffold, Christian Kammertoens, Thomas Oelmann, Elisabeth Silling, Gerda Berdel, Wolfgang E. Kienast, Joachim |
| Copyright Year | 2004 |
| Abstract | Cure of hematologic malignancies after allogeneic hematopoietic stem cell transplantation is partially attributable to immunocellular antitumor reactions termed graft-versus-tumor (GvT) effect. GvT effects are heterogeneous with respect to effector cell populations, target antigens, and their interrelation with graft-versus-host disease (GvHD). In the present study, allogeneic parent-into-F1 murine transplantation models (BALB/c or C57BL/6 --> [C57BL/6 x BALB/c]F1) with different tumors derived from either parental strain were used to evaluate tumor-specific GvT effects. Compared with syngeneic F1-into-F1 controls, significant CD8+ T cell-mediated GvT effects occurred in both allogeneic transplantation models, even in the absence of histoincompatibilities between donor cells and host tumor. Identical genetic background of donor and tumor precluded allorecognition of tumor cells, indicating that tumor-associated antigens (TAAs) were targeted. With allowance made for selective major histocompatibility complex (MHC) disparities between donor cells and normal host tissue, GvHD was identified as a driving force for TAA-specific GvT effects. Adoptive transfer of the effector cells into secondary tumor-bearing recipients confirmed sustained antitumor activity and specificity of the T-cell response. The results provide experimental proof of a donor CD8+ T cell-mediated TAA-specific antitumor response in vivo that is driven by GvHD. It may represent one of the mechanisms contributing to GvT effects observed in allogeneic transplant recipients. |
| File Format | PDF HTM / HTML |
| DOI | 10.1182/blood-2003-10-3387 |
| PubMed reference number | 15090450 |
| Journal | Medline |
| Volume Number | 104 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/104/4/1210.full.pdf?sso-checked=true |
| Alternate Webpage(s) | https://doi.org/10.1182/blood-2003-10-3387 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
