In vitro evaluation of glutathione peroxidase (GPx)-like activity and antioxidant properties of some Ebselen analogues.

Content Provider	Semantic Scholar
Author	Mareque, Ange Mouithys-Mickalad Faez, Juan Mareque Chistiaens, Léon Kohnen, Stephan Deby, Carol Hoebeke, Maryse Lamy, Maurice Deby-Dupont, Ginette
Copyright Year	2004
Abstract	Four analogues of Ebselen were synthesized and their glutathione peroxidase activity and antioxidant property evaluated and compared to Ebselen. Among the studied compounds, only diselenide [3] exhibited both glutathione peroxidase activity and radical-scavenging capability. Compounds [3] and [4] showed a strong inhibitory effect (53% and 43%, respectively) on the lipid peroxidation of linoleic acid compared to Ebselen and selenide derivatives ([1] and [2]) which were less active (28%, 26% and 18% inhibition, respectively). A concentration-dependent inhibitory effect was also found in the model of the formation of ABTS*+ radical cation: 65% and 89% inhibition for compound [3] at 10(-4) M and 5 x 10(-5) M, respectively, and 68% and 90% for compound [4], compared to 14% and 52% inhibition for Ebselen and the diselenides [1] and [2] (29%, 46% and 45%, 68%, respectively). By EPR spin trapping technique, the following inhibitory profile of the Ebselen analogues was observed towards the formation of thiyl radicals: Ebselen = [3]>[1]>[2]>[4]. Studies with compound [3] are in progress on oxidative stress cell models.
File Format	PDF HTM / HTML
DOI	10.1179/135100004225004788
PubMed reference number	15231062
Journal	Medline
Volume Number	9
Issue Number	2
Alternate Webpage(s)	http://orbi.ulg.ac.be/bitstream/2268/62722/1/article17.pdf
Alternate Webpage(s)	https://doi.org/10.1179/135100004225004788
Journal	Redox report : communications in free radical research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article