Prevalence of cognitive impairment in major depression and bipolar disorder.

Content Provider	Semantic Scholar
Author	Douglas, Katie M. Gallagher, Peter F. Robinson, Lucy J. Carter, Janet Deborah Mcintosh, V. V. Frampton, Chris Watson, Stuart Young, Allan H. Ferrier, I. Nicol Porter, Richard J.
Copyright Year	2018
Abstract	OBJECTIVES The current study examines prevalence of cognitive impairment in four mood disorder samples, using four definitions of impairment. The impact of premorbid IQ on prevalence was examined, and the influence of treatment response. METHODS Samples were: (i) 58 inpatients in a current severe depressive episode (unipolar or bipolar), (ii) 69 unmedicated outpatients in a mild to moderate depressive episode (unipolar or bipolar), (iii) 56 outpatients with bipolar disorder, in a depressive episode, and (iv) 63 outpatients with bipolar disorder, currently euthymic. Cognitive assessment was conducted after treatment in Studies 1 (6 weeks of antidepressant treatment commenced on admission) and 2 (16-week course of cognitive behaviour therapy or schema therapy), allowing the impact of treatment response to be assessed. All mood disorder samples were compared with healthy control groups. RESULTS The prevalence of cognitive impairment was highest for the inpatient depression sample (Study 1), and lowest for the outpatient depression sample (Study 2). Substantial variability in rates was observed depending on the definition of impairment used. Correcting cognitive performance for premorbid IQ had a significant impact on the prevalence of cognitive impairment in the inpatient depression sample. There was minimal evidence that treatment response impacted on prevalence of cognitive impairment, except in the domain of psychomotor speed in inpatients. CONCLUSIONS As interventions aiming to improve cognitive outcomes in mood disorders receive increasing research focus, the issue of setting a cut-off level of cognitive impairment for screening purposes becomes a priority. This analysis demonstrates important differences in samples likely to be recruited depending on the definition of cognitive impairment and begins to examine the importance of premorbid IQ in determining who is impaired.
Starting Page	260
Ending Page	274
Page Count	15
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.cogstate.com/wp-content/uploads/2018/02/Douglas_et_al-2018-Bipolar_Disorders.pdf
PubMed reference number	29345037v1
Alternate Webpage(s)	https://doi.org/10.1111/bdi.12602
DOI	10.1111/bdi.12602
Journal	Bipolar disorders
Volume Number	20
Issue Number	3
Language	English
Access Restriction	Open
Subject Keyword	Antidepressive Agents Behavior Therapy Bipolar Disorder Cognition Disorders Cognitive Therapy Impacted tooth Impaired cognition Major Depressive Disorder Mood Disorders Outpatients inpatient
Content Type	Text
Resource Type	Article