NDLI: Ximelagatran, a new oral direct thrombin inhibitor, for the prevention of venous thromboembolic events in major elective orthopaedic surgery. Efficacy, safety and anaesthetic considerations.

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Ximelagatran, a new oral direct thrombin inhibitor, for the prevention of venous thromboembolic events in major elective orthopaedic surgery. Efficacy, safety and anaesthetic considerations.

Content Provider	Semantic Scholar
Author	Rosencher, Nadia
Copyright Year	2004
Abstract	The oral direct thrombin inhibitor ximelagatran shows great promise for prevention of venous thromboembolic events following major elective orthopaedic surgery. Its consistent and predictable pharmacokinetics and pharmacodynamics across a wide range of patient populations allow administration with fixed dosing and with no coagulation monitoring. In orthopaedic surgery clinical trials, ximelagatran was effective and well tolerated compared with standard therapy, with dose and timing relative to surgery important factors in determining its optimal profile. In European trials, an initial 3-mg postoperative dose of subcutaneous melagatran, the active form of ximelagatran, followed by oral ximelagatran 24 mg twice daily achieved similar efficacy and safety to enoxaparin. Although the risk of spinal haematoma following neuraxial anaesthesia is rare, it is increased by the concomitant use of anticoagulants. In orthopaedic surgery trials with ximelagatran to date, complications such as spinal haematoma have not been reported. The pharmacokinetic profile of ximelagatran suggests that concurrent use with neuraxial anaesthesia should require no further precautions than those currently necessary with low-molecular-weight heparin.
Starting Page	7086
Ending Page	7087
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.tromboembolismo.com/doc/doc2.pdf
PubMed reference number	15270973v1
Volume Number	59
Issue Number	8
Journal	Anaesthesia
Language	English
Access Restriction	Open
Subject Keyword	Anticoagulants Enoxaparin Hematoma Heparin, Low-Molecular-Weight Patients Pharmacodynamics Venous Thromboembolism heparin melagatran ximelagatran
Content Type	Text
Resource Type	Article

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