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Oxidation of Thiamine: Kinetic and Mechanistic Study by Hexacyanoferrate (iii) in Aqueous Alkaline Media
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shimpi, Ravindra Fadat, Rajesh Bhaurao Dobhal, Bhagwansing Shivsing Janrao, Dnyandeo M. Farooqui, Mazahar |
| Copyright Year | 2014 |
| Abstract | The kinetics of oxidation of thiamine by hexacyanof errate (abbreviated as HCF) (III) ions in aqueous alkaline medium at constant ionic strength 0.0016 m ol/dm 3 and temperature 298K has been studied spectrophotometrically. The reaction shows 1:2subst rate to oxidant stoichiometry and follows first ord er kinetics in (alkali). The dependence of the rate on substrate and (HCF (III)) concentration has been f ound to be of fractional order type. The ionic strength of the reaction mixture shows positive salt effect on the reaction rate. To calculate thermodynamic parameters the reaction has been studied at six different temperatures from 283K to 333K. Mechanism involving formation of complex between hexacyanoferrate and thiamine has been proposed. 2-(3-((4-Amino-2-methyl-pyrimidin-5-yl) methyl)-4-methyl-thiazol-5-yl) ethanol have been identified chromatographically an d spectroscopically as the final product of oxidati on of thiamine. Based on the kinetic data and product ana lysis a reaction mechanism is proposed. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ajrcps.com/article/OXIDATION%20OF%20THIAMINE%20KINETIC%20AND%20MECHANISTIC%20STUDY%20BY%20HEXACYANOFERRATE%20(III)%20IN%20AQUEOUS%20ALKALINE%20MEDIA.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
