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A designed protein with packing between left-handed and right-handed helices.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sia, Samuel K. Kim, Peter S. |
| Copyright Year | 2001 |
| Abstract | A common motif in protein structures is the assembly of alpha-helices. Natural alpha-helical assemblies, such as helical bundles and coiled coils, consist of multiple right-handed alpha-helices. Here we design a protein complex containing both left-handed and right-handed helices, with peptides of D- and L-amino acids, respectively. The two peptides, D-Acid and L-Base, feature hydrophobic heptad repeats and are designed to pack against each other in a "knobs-into-holes" manner. In solution, the peptides form a stable, helical heterotetramer with tight packing in the most solvent-protected core. This motif may be useful for designing protease-resistant, helical D-peptide ligands against biological protein targets. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/bi010725v |
| PubMed reference number | 11467960 |
| Journal | Medline |
| Volume Number | 40 |
| Issue Number | 30 |
| Alternate Webpage(s) | https://static1.squarespace.com/static/562d385fe4b0e2b30b0c79b4/t/563bebb1e4b0a0477939da69/1446767537212/104-Ref-Kim_Lab.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/bi010725v |
| Journal | Biochemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
