NDLI: Low adiponectin blood concentration predicts left ventricular remodeling after ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.

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Low adiponectin blood concentration predicts left ventricular remodeling after ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.

Content Provider	Semantic Scholar
Author	Piestrzeniewicz, Katarzyna Luczak, Katarzyna Maciejewski, Marek Drozdz, Jaroslaw
Copyright Year	2010
Abstract	BACKGROUND Left ventricular remodeling (LVR), an increase in left ventricular end-diastolic volume index > or = 20%, is an adverse consequence of myocardial infarction. The aim of this study was to assess the association between LVR and adiponectin, which has been shown to protect against myocardial ischemia-reperfusion injury. METHODS In 75 patients echocardiographic examination was performed one year after ST-segment elevation myocardial infarction, successfully treated with primary percutaneous coronary intervention (pPCI). Two groups of patients were analyzed: those with LVR (n = 15) and those without LVR (n = 60). RESULTS The predictors of LVR were: anterior myocardial infarction, glucose at admission, baseline C-reactive protein, adiponectin, and echocardiographic parameters: left ventricular end-diastolic and end-systolic volume indices, ejection fraction < 40% and left ventricular wall motion score index (WMSI) at discharge. On multivariable regression analysis, lower adiponectin level (OR = 0.67, 95% CI 0.49-0.91, p < 0.05) and higher WMSI (OR = 20.14, 95% CI 2.62-154.82, p < 0.01) were the only independent negative predictors of LVR. The optimal cut-off for adiponectin for predicting LVR was < or = 4.7 mg/mL (sensitivity: 73%, specificity: 85%) and this level increased the risk of LVR 15-fold (95% CI 4.05-59.87, p = 0.0001). CONCLUSIONS Baseline low blood adiponectin concentration, along with WMSI, can be considered as a predictor of the LVR in male patients one year after myocardial infarction and pPCI.
Starting Page	49
Ending Page	56
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	20104457
Journal	Medline
Volume Number	17
Issue Number	1
Alternate Webpage(s)	http://www.cardiologyjournal.org/en/darmowy_pdf.phtml?id=94&indeks_art=1278
Journal	Cardiology journal
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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