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In Situ Gels-a New Trends in Ophthalmic Drug Delivery Systems
| Content Provider | Semantic Scholar |
|---|---|
| Author | Saini, Ram Chander Saini, Seema Singh, Gurpreet Banerjee, Angshu |
| Copyright Year | 2015 |
| Abstract | Ophthalmic drug delivery is one of the most interesting and challenging endeavor facing the pharmaceutical scientist. The conventional ocular drug delivery systems like solutions, suspensions, and ointments show drawbacks such as increased precorneal elimination, high variability in efficiency, and blurred vision respectively so there was a need for developing advanced drug delivery system. In situ forming polymeric formulations were developed to overcome the conventional drug therapy drawbacks these systems are in solution form before administering in the body, but once administered these systems undergo gelation. The formation of gels depends on factors like change in a specific physico-chemical parameter (pH, temperature, ion-sensitive) by which the drug gets released in a sustained and controlled manner. These systems were evaluated for drug content, clarity, pH, gelling capacity, viscosity, in vitro drug release studies, texture analysis, sterility testing , isotonicity evaluation, accelerated studies and irritancy test. FT-IR spectroscopy was used to know drug and polymer incompatibilities. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ijpsr.info/docs/IJPSR15-06-05-027.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
