NDLI: Central ventilatory effects of thyrotropin-releasing hormone in the conscious rat

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Central ventilatory effects of thyrotropin-releasing hormone in the conscious rat

Content Provider	Semantic Scholar
Author	Vonhof, Stefan Feuerstein, Giora Z.
Copyright Year	1991
Abstract	Thyrotropin-releasing hormone was shown to exert potent ventilatory effects after central administration. These data, however, were derived from studies using anesthetized animal preparations. Since TRH elicits strong arousal reactions, the observed ventilatory effects of TRH under anesthesia may have been due to nonspecific reduction in the anesthetic state of the animals. In order to clarify the extent to which the reversal of anesthesia may change ventilatory parameters after TRH application, we investigated the effect of TRH on ventilation rate, relative tidal volume, relative respiratory minute volume, CO2 production CO2 consumption, and locomotor activity in the conscious, unrestrained rat. Intracerebroventricular application of TRH induced a dose-dependent, sustained increase in ventilation rate, relative tidal volume, and relative respiratory minute volume of maximally 128%, 890%, and 235%, respectively. In addition, CO2 production and O2 consumption were elevated by 4.6 and 11.7 fold, while no significant changes in locomotor activity were observed. The results suggest that TRH stimulates ventilation by a mechanism independent of its analeptic properties.
Starting Page	93
Ending Page	98
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/0143-4179(91)90007-6
PubMed reference number	1901964
Journal	Medline
Volume Number	18
Alternate Webpage(s)	https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/deliver/index/docId/6071/file/Siren21.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0143417991900076
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0143417991900076?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0143-4179%2891%2990007-6
Journal	Neuropeptides
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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