NDLI: Antimicrobial Activity of Sodium chlorate and Korean Herbal Extracts against Mice infected with Escherichia coli O157:H7

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Antimicrobial Activity of Sodium chlorate and Korean Herbal Extracts against Mice infected with Escherichia coli O157:H7

Content Provider	Semantic Scholar
Author	Cha, Chun-Nam Lee, Yeo-Eun Son, Song-Ee Park, Eun-Kee Choi, Hyunju Lee, Hu-Jang
Copyright Year	2012
Abstract	ABSTRACT - The present study was evaluated the antibacterial effect of the combination of Coptidis rhizoma,Glycyrrhiza uralensis Fischet, Schizandra chinensis and Corni Fructus(1:1:1) extracts(CGSC10). Furthermore, theeffectiveness of CGSC10, sodium chlorate, and the combination of CGSC10 and sodium chlorate(CGSCS10) againstE. coli O157:H7 infection was studied using ICR female mice. During the incubation period, the dose of 5, 10, and20% CGSC10 was inhibited the growth of E. coli O157:H7 by 34.7, 60.2, and 76.4%, respectively. For 7 days aftersingle challenge with E. coli O157:H7, forty female ICR mice were divided into four experimental groups which wereadministered in drinking water with saline, 10% CGSC10, 15 mM sodium chlorate, and CGSCS10, respectively. Onthe 3rd day, the number of E. coli O157:H7 in mouse feces was significantly decreased by administration of CGSC10,15 mM sodium chlorate, and CGSCS10 (p < 0.001). On the 7th day-after administration, CGSC10, sodium chlorate,and CGSCS10 were decreased the number of E. coli O157:H7 by 27.1, 67.7, and 83.3%, respectively. According tothe results of the present study, administration of CGSCS10 to mice can reduce the severity of E. coli O157:H7 infec-tion. In addition, it is suggested that CGSCS10 represents a good candidate for the treatment of enteric infections indomestic animals. Key words: Korean traditional herbal extracts, sodium chlorate, antibacterial activity, E. coli O157:H7
Starting Page	81
Ending Page	86
Page Count	6
File Format	PDF HTM / HTML
DOI	10.13103/JFHS.2012.27.1.081
Volume Number	27
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/ksfhs/SPOHBV/2012/v27n1/SPOHBV_2012_v27n1_81.pdf
Alternate Webpage(s)	https://doi.org/10.13103/JFHS.2012.27.1.081
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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