NDLI: Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts.

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Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts.

Content Provider	Semantic Scholar
Author	Westra, Jantine L. Limburg, Pieter C. Boer, Piet A. J. De Rijswijk, Martin H. Van
Copyright Year	2004
Abstract	OBJECTIVE To investigate the effect of the p38 mitogen activated protein kinase (MAPK) inhibitor RWJ 67657 on inflammatory mediator production by rheumatoid synovial fibroblasts (RSF). METHODS RSF were pretreated with RWJ 67657 and stimulated with TNF alpha and/or IL-1 beta. Protein levels and mRNA expression of MMP-1, MMP-3, TIMP-1, IL-6, and IL-8 were determined, as was mRNA expression of COX-2 and ADAMTS-4. RESULTS MMP-3 production was significantly inhibited at 1 microM RWJ 67657 and MMP-1 production at 10 microM, while TIMP-1 production was not inhibited. Inhibition of IL-6 and IL-8 protein production was seen at 0.1 microM RWJ 67657. Expression profiles of mRNA were in accordance with protein production. Inhibition of COX-2 mRNA expression occurred at 0.01 microM RWJ 67657. CONCLUSIONS RWJ 67657 inhibits major proinflammatory mediator production in stimulated RSF at pharmacologically relevant concentrations. These findings could have important relevance for the treatment of rheumatoid arthritis.
Starting Page	9
Ending Page	23
Page Count	15
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ard.bmj.com/content/annrheumdis/63/11/1453.full.pdf
PubMed reference number	15479895v1
Volume Number	63
Issue Number	11
Journal	Annals of the rheumatic diseases
Language	English
Access Restriction	Open
Subject Keyword	ADAMTS3 gene Interleukin-1 beta MAPK14 protein, human Matrix Metalloproteinase 3 Mediator brand of benfluorex hydrochloride Mitogen-Activated Protein Kinases Mitogens RSF1 wt Allele Rheumatoid Arthritis TIMP1 protein, human
Content Type	Text
Resource Type	Article

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