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Age-related dendritic and spinal alterations of pyramidal cells of the human visual cortex.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mavroudis, Ioannis Asterios Manani, Marina George Petrides, Foivos E. Dados, Dimitrios Ciobica, Alin Pădurariu, Manuela Petsoglou, Konstantina Njau, Samuel Ndugu Costa, Vasiliki George Baloyannis, Stavros John |
| Copyright Year | 2015 |
| Abstract | INTRODUCTION Normal aging is characterized by deterioration of visual abilities, affecting mainly visual acuity, contrast and wavelength sensitivity. In the present study we attempted to describe the morphological and morphometric alterations of the dendrites and the dendritic spines of the pyramidal cells of the visual cortex during normal aging, in order to approach the visual impairment of aged individuals from a neuropathological point of view. MATERIAL AND METHODS We studied the visual cortex in 20 brains using the Golgi technique. RESULTS In pyramidal cells, which represent the majority of cortical neurons, age-related pathology can be observed in cell somata as well as, most importantly, in dendrite number and morphology. The apical dendrites of some pyramidal cells are distorted and tortuous. Horizontal dendritic arborization is also severely decreased. These alterations were more prominent in the corticocortical pyramidal neurons of the 5th layer. CONCLUSIONS The morphological and morphometric assessment of the dendrites and the dendritic spines in the visual cortex in normal aging revealed substantial alterations of the dendritic arborization and marked loss of the dendritic spines, which may be related to visual impairment even in normal aging. |
| Starting Page | 1726 |
| Ending Page | 1731 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.termedia.pl/Journal/-20/pdf-25333-10?filename=Age+related.pdf |
| Alternate Webpage(s) | https://www.termedia.pl/Journal/-20/pdf-25333-10?filename=Age+related.pdf |
| PubMed reference number | 26216112v1 |
| Volume Number | 53 |
| Issue Number | 2 |
| Journal | Folia neuropathologica |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Area striata structure Attempt Brain Cerebral cortex Dendrites Dendritic Spines Pyramidal Cells Vertebral column |
| Content Type | Text |
| Resource Type | Article |
