Loading...
Please wait, while we are loading the content...
Similar Documents
Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhao, Qian Xu, Wen-Ting Shalieer, Tuluhong |
| Copyright Year | 2016 |
| Abstract | Objective. In the current study, we measured the expression status of melanoma antigen gene c2 (MAGE-C2) in triple-negative breast cancer (TNBC) and analyzed its prognostic with the clinical pathological features of patients with TNBC. Methods. The expressions statuses of MAGE-C2 were detected in TNBC tissues and paracarcinoma tissues by immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR), and western blotting. Then, we investigated the relationship of MAGE-C2 expression status and clinicopathological parameters of TNBC patients by the chi-squared test. Finally, we discussed the relations of MAGE-C2 expression state and prognosis of patients with TNBC by Kaplan-Meier method and Cox proportional hazards model. Results. High MAGE-C2 expression was found in 38.18% (42/110) of TNBC tissues. In adjacent tissues it was 9.09% (10/110). High MAGE-C2 expression in TNBC patients was closely associated with lymph node status, tumor node metastasis (TNM) stage, and lymphovascular invasion (P < 0.001). TNBC patients with high MAGE-C2 expression had significantly shorter survival time than low expression patients. We also found that age, lymph node status, TNM stage, lymphovascular invasion, and MAGE-C2 expression status were closely associated with overall survival of TNBC patients (P < 0.05). Conclusion. High MAGE-C2 expression may serve as an independent prognostic factor for TNBC patients. |
| Starting Page | 87 |
| Ending Page | 108 |
| Page Count | 22 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://downloads.hindawi.com/journals/dm/2016/2325987.pdf |
| PubMed reference number | 27843173v1 |
| Volume Number | 2016 |
| Journal | Disease markers |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic Node Biological Markers Body tissue Breast Carcinoma Hepatitis C virus c2 Ab:PrThr:Pt:Ser:Ord:IB Lymph Node Tissue Malignant neoplasm of breast Mammary Neoplasms Melanoma-Associated Antigen Family MicroArray and Gene Expression Overall Survival Patients Prognostic Factors Reverse Transcriptase Polymerase Chain Reaction Reverse Transcription Triple Negative Breast Neoplasms Western Blotting lymph nodes pediatric intracranial germ cell brain tumor |
| Content Type | Text |
| Resource Type | Article |
