Loading...
Please wait, while we are loading the content...
Similar Documents
Valsartan restores sarcoplasmic reticulum function with no appreciable effect on resting cardiac function in pacing-induced heart failure.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Okuda, Shinichi Yano, Masafumi Doi, Masahiro Oda, Tetsuro Tokuhisa, Takahiro Kohno, Masateru Kobayashi, Shigeki Yamamoto, Takeshi Ohkusa, Tomoko Matsuzaki, Masunori |
| Copyright Year | 2004 |
| Abstract | BACKGROUND Although angiotensin II receptor blockade is considered to be useful for the treatment of human heart failure, little beneficial hemodynamic effect has been shown in some experimental failing hearts. In this study, we assessed the effect of an angiotensin II receptor blocker, valsartan, on sarcoplasmic reticulum (SR) function, defectiveness of which is a major pathogenic mechanism in heart failure. METHODS AND RESULTS SR vesicles were isolated from dog left ventricular muscle (normal or exposed to 4-week rapid ventricular pacing with or without valsartan). In the untreated and valsartan-treated paced dogs, cardiac function showed similar deterioration (compared with before pacing). However, both the density of beta-receptors and the contractile response to dobutamine were greater in the valsartan-treated paced dogs than in the untreated paced dogs. In untreated paced hearts, the ryanodine receptor was protein kinase A-hyperphosphorylated, showed an abnormal Ca2+ leak, and had a decreased amount of ryanodine receptor-bound FKBP12.6. No such phenomena were seen in the valsartan-treated paced hearts. Both the SR Ca2+ uptake function and the amount of Ca2+-ATPase were decreased in the untreated failing SR, but both were restored in the valsartan-treated SR. CONCLUSIONS During the development of pacing-induced heart failure, valsartan preserved the density of beta-receptors and concurrently restored SR function without improving resting cardiac function. |
| Starting Page | 391 |
| Ending Page | 400 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/109/7/911.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/109/7/911.full.pdf?download=true |
| PubMed reference number | 14757694v1 |
| Volume Number | 109 |
| Issue Number | 7 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angiotensin II Angiotensins Biologic Preservation Calcium ion Canis familiaris Dobutamine Heart failure Hemodynamics Muscle Myalgia Protein Kinases Rest Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Vesicle (morphologic abnormality) valsartan |
| Content Type | Text |
| Resource Type | Article |
