Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans.

Content Provider	Semantic Scholar
Author	Proctor, Susan P. Heaton, Kristin J. Heeren, Tim White, Roberta F.
Copyright Year	2006
Abstract	BACKGROUND During the Gulf War (GW), in early March 1991, a munitions dump at Khamisiyah, Iraq, was destroyed. Later, in 1996, the dump was found to have contained the organophosphate chemical warfare agents, sarin and cyclosarin. METHODS Data collected in a study conducted between 1994 and 1996, before the Khamisiyah incident was publicly disclosed, were used to examine neurobehavioral task performances of GW veterans (n=140) categorized as having received high, moderate, or low-to-no exposure dose levels to sarin and cyclosarin at Khamisiyah, Iraq. Exposure levels were based on modeled estimates of the exposure plume and on troop location information at the time of the Khamisiyah event. Based on recent findings observed in follow-up studies of persons exposed to sarin during the 1995 terrorist attacks in Japan, we hypothesized that exposure to sarin and cyclosarin would be associated with poorer performances on objective neurobehavioral tasks in specific functional domains (particularly in visuospatial abilities and psychomotor functioning) in a dose-dependent manner. RESULTS Sarin and cyclosarin exposure was significantly associated with less proficient neurobehavioral functioning on tasks involving fine psychomotor dexterity and visuospatial abilities 4-5 years after exposure. CONCLUSIONS Findings suggest a dose-response association between low-level exposure to sarin and cyclosarin and specific functional central nervous system effects 4-5 years after exposure.
File Format	PDF HTM / HTML
DOI	10.1016/j.neuro.2006.08.001
PubMed reference number	16982099
Journal	Medline
Volume Number	27
Issue Number	6
Alternate Webpage(s)	https://www.safetylit.org/citations/ild_request_form.php?article_id=citjournalarticle_375023_38
Alternate Webpage(s)	https://doi.org/10.1016/j.neuro.2006.08.001
Journal	Neurotoxicology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article