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Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ge, Minghua Chen, Chao Xu, Jia-Jie Ling, Zhi-Qiang |
| Copyright Year | 2011 |
| Abstract | To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the corresponding normal salivary glands, respectively, achieving a significant difference (P<0.001). There was a significant correlation between RUNX3 methylation and various clinicopathological parameters of ACCs, such as perineural invasion, lymph node involvement, T-stage and distant metastasis (P<0.001). RUNX3 methylation was a significant predictor of the 5-year disease-free survival in ACC patients after surgery. Partial methylation was found in all 3 ACC cell lines, and the reactivation and more potent expression of RUNX3 was induced by 5-triazole-2-deoxycytidine. Our findings indicate that RUNX3 methylation may occur as a common event in the development of ACC and that methylation may be a major mechanism for inactivation of RUNX3 in ACC. |
| File Format | PDF HTM / HTML |
| DOI | 10.3892/or.2011.1282 |
| PubMed reference number | 21567090 |
| Journal | Medline |
| Volume Number | 26 |
| Issue Number | 2 |
| Alternate Webpage(s) | https://www.spandidos-publications.com/or/26/2/349/download |
| Alternate Webpage(s) | https://doi.org/10.3892/or.2011.1282 |
| Journal | Oncology reports |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
