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Change of retinal pigment epithelial atrophy after anti-vascular endothelial growth factor treatment in exudative age-related macular degeneration
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kim, Moosang Kim, Eung Suk Seo, Kyung Hoon Yu, Seung-Young Kwak, Hyung-Woo |
| Copyright Year | 2016 |
| Abstract | Purpose: The study aimed to investigate the quantitative changes of retinal pigment epithelial (RPE) atrophy during a 24-month follow-up period of anti-vascular endothelial growth factor (VEGF) for exudative age-related macular degeneration (AMD). Materials and Methods: This is a retrospective study. Sixty-five eyes of 62 consecutive patients with naοve exudative AMD who had received treatment with anti-VEGF therapy and followed for more 24 months were enrolled. All patients received three initial monthly injections of anti-VEGF (ranibizumab or bevacizumab), followed by pro re nata or treat-and-extend protocol. Color fundus image, optical coherence tomography, and fundus autofluorescence were evaluated for RPE atrophy. Multiple regression analysis was performed to investigate the predictive factors found during univariate analysis to identify an association with increased RPE atrophic areas. Results: The mean number of anti-VEGF treatments was 9.18. RPE atrophic area was 1.293 ± 1.298 mm 2 at baseline and enlarged to 2.394 ± 1.940 mm 2 after 24 months, which differed significantly (P = 0.001). Multiple regression analysis revealed that larger areas of RPE atrophy at month 4 and larger numbers of anti-VEGF treatments were associated with increased RPE atrophic areas. Conclusions: RPE atrophy progresses in eyes with exudative AMD during anti-VEGF treatment. Larger areas of RPE atrophy at month 4 and larger numbers of anti-VEGF injections were associated with an increased risk of progression of RPE atrophy the following treatment. These findings may be useful to clinicians using intravitreal anti-VEGF for the treatment of exudative AMD, both for selecting an appropriate treatment plan and for predicting the progression of RPE atrophy. |
| Starting Page | 427 |
| Ending Page | 433 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.4103/0301-4738.187659 |
| PubMed reference number | 27488150 |
| Journal | Medline |
| Volume Number | 64 |
| Journal | Indian journal of ophthalmology |
| Alternate Webpage(s) | http://apris.asia/file/2016_abstract/s3_03.pdf |
| Alternate Webpage(s) | https://doi.org/10.4103/0301-4738.187659 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
