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Bite-raised condition transiently activates microglia in the mouse hippocampal CA1 but not in the dentate gyrus
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kojo, Akiko Yamada, Kentaro Yamashita, Anzu Yamamoto, Toshiharu Onozuka, Minoru |
| Copyright Year | 2009 |
| Abstract | Cilia are evolutionary conserved organelles that are classified into either conventional (motile) or primary (nonmotile). Compared with the conventional cilia whose functions are well known, the physiological function and significance of primary cilia are largely unknown, except for its pivotal role in early vertebrate development. Recent studies have shown that primary cilia brought together receptors and signal transduction components, such as Wnt and Hedgehog (Hh) signaling pathway. Although previous studies have shown that molecules for Hh signaling cascade are active in various cells during development, their physiological functions in the nervous system, especially in glial cells, are still enigmatic. In this study, we identified primary cilia in several types of glial cells. Moreover, Hh signaling molecules were accumulated on the primary cilia. Our studies indicate that Hh signaling via primary cilia playa an important role in proliferation and survival of glial cells under stressed condition of the cell. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neures.2009.09.357 |
| Volume Number | 65 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0168010209006270 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0168010209006270?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neures.2009.09.357 |
| Journal | Neuroscience Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
