Loading...
Please wait, while we are loading the content...
Similar Documents
Prognostic Value of Cardiopulmonary Exercise Test in Elderly Women with Heart Failure and Reduced or Preserved Ejection Fraction
| Content Provider | Semantic Scholar |
|---|---|
| Author | Scardovi, Angela Beatrice Maria, Renata De Ferraironi, Alessandro Renzi, Marco Turi, Franco Parolini, Marina Giacomo, Tiziana Di Ricci, Roberto |
| Copyright Year | 2014 |
| Abstract | The prognostic role of cardiopulmonary exercise test (CPET) in elderly women with chronic heart failure (HF) has not yet been clarified. We assessed the incremental value of CPET variables for risk stratification in female HF patients with preserved or reduced left ventricular ejection fraction (LVEF). We prospectively followed up 131 female HF outpatients aged 72 [interquartile range 62 77] years after a symptom limited CPET. 34% had ischemic heart disease and 14% permanent atrial fibrillation, 24% were in NYHA class III. LVEF was 50% [interquartile range 36 62], peak oxygen consumption was 11.3 [interquartile range 9.2 13.5] ml/kg/min; the slope of the regression line relating ventilation to CO2 output was 33.9 [interquartile range 30.3 44.9]; 40% of patients showed exercise oscillatory breathing during CPET. During a median follow-up of 18 months [interquartile range 8 54], overall 39 patients (29.7%) met the combined end-point of cardiovascular mortality or HF admission using a time-to-first event approach. Moderate to severe mitral regurgitation, slope, exercise oscillatory breathing were independently associated to cardiovascular mortality or HF admission. When CPET ventilatory variables were added to clinical and echocardiographic parameters, prediction of the combined point improved significantly (AUC 0.755 (95% CI 0.662 to 0.832) vs 0.634 (95% CI 0.536 to 0.725), p = 0.016). In conclusion, among elderly female HF patients the CPET derived parameters EOB and VE/VCO2 slope emerged as strong prognostic markers, with additive predictive value to clinical and echocardiographic parameters in patients with both reduced and preserved LVEF. Corresponding author. A. B. Scardovi et al. 342 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://file.scirp.org/pdf/WJCD_2014061210241983.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Area Under Curve Atrial Fibrillation Biologic Preservation Carbon Dioxide Cardiopulmonary Exercise Test Ejection fraction (procedure) Exercise stress test Eye of the Beholder Heart Atrium Heart Diseases Heart failure Helicon Focus Increment Interquartile Range Left ventricular ejection fraction Maxima and minima Milliliter per Kilogram per Minute Mitral Valve Insufficiency Myocardial Ischemia Oxygen Consumption Patients Regurgitation Respiration Stratification Utility functions on indivisible goods |
| Content Type | Text |
| Resource Type | Article |
