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IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kuen, Da-Sol Kim, Byung-Seok Chung, Yeonseok |
| Copyright Year | 2020 |
| Abstract | IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8+ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or anti-tumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed. |
| File Format | PDF HTM / HTML |
| DOI | 10.4110/in.2020.20.e6 |
| PubMed reference number | 32158594 |
| Journal | Medline |
| Volume Number | 20 |
| Journal | Immune network |
| Alternate Webpage(s) | https://immunenetwork.org/Synapse/Data/PDFData/0078IN/in-20-e6.pdf |
| Alternate Webpage(s) | https://doi.org/10.4110/in.2020.20.e6 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
