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Spectrophotometric Determination of Methyldopa in Pharmaceutical Preparation Via Oxidative Coupling Organic Reaction with Para-Phenylenediamine in the Presence of Potassium Periodate
| Content Provider | Semantic Scholar |
|---|---|
| Author | Al-Da'amy, Muneer. A. . Al-Moswi, Rashwan . F. |
| Copyright Year | 2014 |
| Abstract | A simple, accurate and sensitive spectrophotometric method for the determination of Methyldopa in pure and pharmaceutical preparations has been developed .The proposed method uses Para-phenylenediamine as anew chromogenic reagent . The method is based on the oxidative coupling reaction of Methyldopa with Para-phenylenediamine with potassium periodate in neutral media to form red water soluble dye product , that has a maximum absorption at λmax 494 nm . Linear calibration graph was in the range of (0.1–10.0) µg.ml-1 with molar absorptivity of (0.61 ×105) L.mol-1.cm-1 ,a sandall sensitivity of (3.91 ×10-6) µg.cm-2 , correlation coefficient of (0.9996) , detection limit (0.025) µg.ml-1 and the relative standard deviation of RSD% (0.99) . The method was applied successfully for the determination of Methyldopa in pharmaceutical preparations and the value of recovery % was better than (100.1%) . |
| Starting Page | 1 |
| Ending Page | 53 |
| Page Count | 53 |
| File Format | PDF HTM / HTML |
| Volume Number | 1 |
| Alternate Webpage(s) | http://www.aessweb.com/pdf-files/5007/12-ICETSR-%20237-%20(160-167).pdf |
| Alternate Webpage(s) | http://www.conscientiabeam.com/ebooks/ICETSR-%20237-%20(160-167).pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
