Loading...
Please wait, while we are loading the content...
Similar Documents
Participação dos receptores hipocampais do neuropeptídeo Y na consolidação e reconsolidação de uma memória aversiva
| Content Provider | Semantic Scholar |
|---|---|
| Author | Linartevichi, Vagner Fagnani |
| Copyright Year | 2017 |
| Abstract | Neuropeptide Y (NPY) has a broad distribution in the central nervous system (CNS) including regions involved with stress regulation and memories processing such as the dorsal hippocampus (DH), amygdala, and prefrontal cortex. In DH, NPY presents its effects mediated mainly by the Y1, Y2 and Y5 receptors. The role of these receptors in some behaviors has already been studied, however, its role in memory modulation needs more investigation. The general aim of the present study was to evaluate the effect of pharmacological manipulation of the Y1 and Y5 receptors in the DH during the memory consolidation and reconsolidation on contextual fear conditioning (CFC) in rats. Our data showed that Y1 and Y5 receptors present an increased immunocontent after CFC, as well as after the infusion of NPY in DH, impairing memory consolidation and reconsolidation. These effects were reproduced with the infusion of selective agonist Y1 and Y5 (Y1r-LP-NPY and Y5r-5RA972, respectively) and were prevented by prior administration of selective antagonists for these receptors. We also observed that during memory consolidation on CFC there was an increase on BDNF and Arc immunocontent that could be prevented by previous NPY administration. The same effect was obtained on Egr1/Zif268 during the memory reconsolidation phase. No effect of NPY was observed during short-term memory, familiarization, or outside the window of consolidation infusion (6 h). During the reconsolidation process, we found that the NPY effect was dependent on memory reactivation, and observed just in the reconsolidation window and there was no reinstallation of the memory. There was no effect on elevated plus-maze (EPM) of all doses of the drugs here used as well as no effect on the immediate shock test. After CFC it appears that occurs a change in the NPY receptor expression dynamics and the pharmacological activation of these receptors seems to impair the memory formation and its maintenance, suggesting a positive role for NPY in stress/fear resilience. On this regard, this NPY-DH mechanism could be a relevant therapeutic approach for some stress-related disorders, such as the posttraumatic stress disorder (PTSD). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://repositorio.ufsc.br/bitstream/handle/123456789/180245/348083.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
