NDLI: Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7.

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Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7.

Content Provider	Semantic Scholar
Author	Jonassen, Tanya Marbois, B. Noelle Kim, Lisa Chin, Angela Xia, Yinglin Rick Lusis, Aldons J. Clarke, Catherine F.
Copyright Year	1996
Abstract	We recently identified the Saccharomyces cerevisiae COQ7 gene and showed that its product affects one or more monoxygenase steps in the synthesis of ubiquinone. Other investigators have independently isolated the yeast COQ7 gene as CAT5 and identified it as a gene necessary for the derepression of gluconeogenic enzymes in yeast. In the present study, a homolog of the yeast COQ7 (CAT5) gene was isolated from a rat testis cDNA library by functional complementation of a coq7 deletion mutant of S. cerevisiae. The resulting cDNA clones contained a 0.8-kb insert with an open reading frame encoding a 183-amino-acid polypeptide. The rat Coq7 amino acid sequence is 49% identical to that of yeast Coq7p and 58% identical to a C. elegans homolog over a 152-aa region. Sequence homology searches fail to identify any other significant homologies. The Coq7 gene was mapped to mouse chromosome 7, 7.6 +/- 3.6 cM proximal to the marker D7Mit7, by linkage analysis of an interspecific backcross. This region of chromosome 7 containing Coq7 is part of a linkage group conserved between mouse chromosome 7 and human chromosome 11p15.
Starting Page	381
Ending Page	400
Page Count	20
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biochemistry.ucla.edu/Faculty/CClarke/pdf/285.pdf
Alternate Webpage(s)	http://www.biochemistry.ucla.edu/biochem/Faculty/CClarke/pdf/285.pdf
PubMed reference number	8660658v1
Volume Number	330
Issue Number	2
Journal	Archives of biochemistry and biophysics
Language	English
Access Restriction	Open
Subject Keyword	11p15 Amino Acid Sequence Amino Acids Biopolymer Sequencing COQ7 gene Chromosomes, Human, Pair 7 Contain (action) DNA, Complementary Deletion Mutation Forty Nine Genes, vif Homologous Gene Open Reading Frames Pierre Robin Syndrome Polypeptides RBFOX1 gene Reading Frames (Nucleotide Sequence) Ubiquinone genetic linkage
Content Type	Text
Resource Type	Article

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