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Low diagnostic accuracy of selective screening criteria for asymptomatic Chlamydia trachomatis infections in the general population.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Valkengoed, Irene G. M. Van Morré, Servaas A. Brule, Adriaan J. C. Van Den Meijer, Chris Jlm Devillé, Walter L. J. M. Bouter, Lex M. Boeke, A. Joan P. |
| Copyright Year | 2000 |
| Abstract | OBJECTIVES To develop and validate selective screening criteria for asymptomatic Chlamydia trachomatis infections in the general population. METHODS 11,505 people, aged 15-40 years, registered in 16 general practices in Amsterdam were invited to return by mail a home obtained first void urine sample and a questionnaire. Participants were randomly allocated into a development group (75%) or a validation group (25%). C trachomatis infection was determined by the ligase chain reaction. In the development group a set of criteria was identified by means of stepwise logistic regression analysis. The diagnostic accuracy (area under the ROC curve; AUC) and sensitivity, and the corresponding percentage of people selected for screening were calculated. The criteria developed in this study were applied to the validation group. RESULTS The prevalence of asymptomatic C trachomatis infections among men was found to be 2.4% (1.7-3.0), and among women 2.8% (2.2-3.4). Screening men, based on Surinam/Antillean origin and painful micturition, yielded an AUC of 0.58 (0.55-0.60). Screening women, based on Surinam/Antillean origin, new sex partner in the previous 2 months, and unmarried/not cohabiting, yielded an AUC of 0.67 (0.65-0.69). Application of the criteria for men to the validation group yielded an AUC of 0.53 (0.48-0.57); by screening 10% of the men, 15% of the cases were detected. The AUC of the criteria for women in the validation group was 0.58 (0.54-0.61); by screening 51% of the women, 63% of the cases were detected. CONCLUSION The prevalence of asymptomatic C trachomatis infections in Amsterdam is less than 3%. No suitable selective screening criteria for the general population could be identified. |
| File Format | PDF HTM / HTML |
| DOI | 10.1136/sti.76.5.375 |
| PubMed reference number | 11141855 |
| Journal | Medline |
| Volume Number | 76 |
| Issue Number | 5 |
| Alternate Webpage(s) | http://sti.bmj.com/content/sextrans/76/5/375.full.pdf |
| Alternate Webpage(s) | https://sti.bmj.com/content/sextrans/76/5/375.full.pdf |
| Alternate Webpage(s) | http://dare.ubvu.vu.nl/bitstream/handle/1871/20439/PMC1744221.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://doi.org/10.1136/sti.76.5.375 |
| Journal | Sexually transmitted infections |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
