Stimulation by a TRH precursor, TRH-Gly, of TSH and PRL secretion in rats: Effect of starvation

Content Provider	Semantic Scholar
Author	Mori, Masatomo Murakami, Matsutaroh Iriuchijima, Tokuji Miyashita, Kakunosuke Kobayashi, S.
Copyright Year	1990
Abstract	The hypophysial activities of a possible direct precursor of thyrotropin (TSH)-releasing hormone (TRH), TRH-Gly, were evaluated in estrogen, progesterone-primed rats under urethane anesthesia. Intravenous administration of TRH-Gly in doses of 2-200 micrograms caused a significant and dose-dependent increase in blood TSH and prolactin (PRL). The stimulatory activity of TRH-Gly was 170 to 400-times less potent than that of TRH. The lower potency was confirmed by the action of TRH-Gly on the anterior pituitary cells in vitro. In starved rats, TRH-Gly apparently stimulated TSH and PRL secretion in a dose-dependent manner, and the stimulatory activity increased in starved rats as compared to normal controls. TRH-Gly did not affect [3H-MeHis]TRH binding in pituitary plasma membranes. These data imply that large amounts of TRH-Gly may have significant biological activities and these are potentiated in the starved condition.
Starting Page	57
Ending Page	62
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/0143-4179(90)90112-C
PubMed reference number	2123526
Journal	Medline
Volume Number	16
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/014341799090112C
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/014341799090112C?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0143-4179%2890%2990112-C
Journal	Neuropeptides
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article