NDLI: Uncaria rhynchophylla induces angiogenesis in vitro and in vivo.

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Uncaria rhynchophylla induces angiogenesis in vitro and in vivo.

Content Provider	Semantic Scholar
Author	Choi, Do-Young Huh, J. E. Lee, Jae-Dong Cho, Eun-Mi Baek, Y. H. Yang, Ha-Ru Cho, Yoon-Je Kim, Kang-Il Kim, Deog-Yoon Park, Dong-Suk
Copyright Year	2005
Abstract	Angiogenesis consists of the proliferation, migration, and differentiation of endothelial cells, and angiogenic factors and matrix protein interactions modulate this process. The aim of this study was to determine the angiogenic properties of Uncaria rhynchophylla. Uncaria rhynchophylla significantly enhanced human umbilical vein endothelial cells (HUVECs) proliferation in a dose-dependent manner. Neutralization of vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) by monoclonal antibody suppressed the Uncaria rhynchophylla stimulatory effect on proliferation. In addition, Uncaria rhynchophylla significantly increased chemotactic-migration on gelatin and tubular structures on Matrigel of HUVECs in a dose-dependent manner. Interestingly, Uncaria rhynchophylla dose-dependently increased VEGF, and bFGF gene expression and protein secretion of HUVEC. The angiogenic activity of Uncaria rhynchophylla was confirmed using an in vivo Matrigel angiogenesis model, showing promotion of blood vessel formation. These results suggest that Uncaria rhynchophylla could potentially used to accelerate vascular wound healing or to promote the growth of collateral blood vessel in ischemic tissues.
Starting Page	578
Ending Page	585
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://bpb.pharm.or.jp/bpb/200512/b12_2248.pdf
PubMed reference number	16327159v1
Volume Number	28
Issue Number	12
Journal	Biological & pharmaceutical bulletin
Language	English
Access Restriction	Open
Subject Keyword	Angiogenic Process Blood Vessel Body tissue Cat's Claw Cerebrovascular Disorders Endothelial Growth Factors Fibroblast Growth Factor 2 Gene Expression Human Umbilical Vein Endothelial Cells Monoclonal Antibodies Protein Secretion Tumor Angiogenesis Umbilicus (Anatomy) Uncaria rhynchophylla stem Wound Healing matrigel
Content Type	Text
Resource Type	Article

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