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Supramolecular Encapsulation of Vitamin B 6 by Macrocyclic Nanocontainer Cucurbit [ 7 ] uril
| Content Provider | Semantic Scholar |
|---|---|
| Author | Li, Wanying Li, Shengke Wyman, Ian W. Macartney, Donal H. Zhang, Qingwen Zheng, Ying Wang, Ruibing |
| Copyright Year | 2015 |
| Abstract | A pharmaceutically and biologically relevant molecule, pyridoxine hydrochloride (vitamin B 6 ), was encapsulated inside the cavity of a molecular container, cucurbit[7]uril (CB[7]), in aqueous solution. The CB[7] based “nanocapsule” of vitamin B 6 has been investigated for the first time, via H NMR and UV-visible spectroscopic titrations (including Job’s plot) and ab initio molecular modeling. The results have demonstrated that vitamin B 6 forms stable host-guest complexes within CB[7] in 1 : 1 stoichiometry, with a binding affinity of (4.0 ± 0.5) × 10M. Such a nanocapsule could potentially find application in vitamin B 6 formulation for the purpose of enhancing the stability, absorption, and delivery of this important vitamin. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://downloads.hindawi.com/journals/jnm/2015/574013.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
