NDLI: A double-blind, placebo-controlled, crossover trial comparing the effects of amiloride and hydrochlorothiazide on glucose tolerance in patients with essential hypertension.

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A double-blind, placebo-controlled, crossover trial comparing the effects of amiloride and hydrochlorothiazide on glucose tolerance in patients with essential hypertension.

Content Provider	Semantic Scholar
Author	Stears, Anna J. Woods, Sarah H. Watts, Michaela M. Burton, Timothy J. Graggaber, Johann Mir, Fraz A. Boekholdt, S. Matthijs
Copyright Year	2012
Abstract	Hypertension guidelines advise limiting the dose of thiazide diuretics and avoiding combination with β-blockade, because of increased risk of diabetes mellitus. We tested whether changes in the 2-hour oral glucose tolerance test could be detected after 4 weeks of treatment with a thiazide and could be avoided by switching to amiloride. Two double-blind, placebo-controlled, crossover studies were performed. In study 1 (41 patients), we found that changes in glucose during a 2-hour oral glucose tolerance test could be detected after 4 weeks of treatment with bendroflumethiazide. In study 2, 37 patients with essential hypertension received, in random order, 4 weeks of once-daily treatment with hydrochlorothiazide (HCTZ) 25 to 50 mg, nebivolol 5 to 10 mg, combination (HCTZ 25-50 mg+nebivolol 5-10 mg), amiloride (10-20 mg), and placebo. Each drug was force titrated at 2 weeks and separated by a 4-week placebo washout. At each visit, we recorded blood pressure and performed a 75-g oral glucose tolerance test. Primary outcome was the difference in glucose (over the 2 hours of the oral glucose tolerance test) between 0 and 4 weeks, when HCTZ and amiloride were compared by repeated-measures analysis. For similar blood pressure reductions, there were opposite changes in glucose between the 2 diuretics (P<0.0001). Nebivolol did not impair glucose tolerance, either alone or in combination. There was a negative correlation between Δpotassium and Δ2-hour glucose (r=-0.28; P<0.0001). In 2 crossover studies, 4 weeks of treatment with a thiazide diuretic impaired glucose tolerance. No impairment was seen with K(+)-sparing diuretic or β(1)-selective blockade. Substitution or addition of amiloride may be the solution to preventing thiazide-induced diabetes mellitus.
Starting Page	4819
Ending Page	4826
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://hyper.ahajournals.org/content/hypertensionaha/early/2012/04/09/HYPERTENSIONAHA.111.189381.full.pdf
Alternate Webpage(s)	http://hyper.ahajournals.org/content/hypertensionaha/59/5/934.full.pdf
Alternate Webpage(s)	http://hyper.ahajournals.org/content/hypertensionaha/59/5/934.full.pdf?download=true
Alternate Webpage(s)	http://hyper.ahajournals.org/content/hypertensionaha/early/2012/04/09/HYPERTENSIONAHA.111.189381.full.pdf?download=true
PubMed reference number	22493073v1
Alternate Webpage(s)	https://doi.org/10.1161/HYPERTENSIONAHA.111.189381
DOI	10.1161/hypertensionaha.111.189381
Journal	Hypertension
Volume Number	59
Issue Number	5
Language	English
Access Restriction	Open
Subject Keyword	Amiloride Bendroflumethiazide Cross-Over Studies Diabetes Mellitus Glucose tolerance test Hydrochlorothiazide Hypertensive disease Impaired glucose tolerance Patients Pulmonary Hypertension Thiazide Diuretics Thiazides nebivolol
Content Type	Text
Resource Type	Article

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