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Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the Northern Finland 1966 Birth Cohort
| Content Provider | Semantic Scholar |
|---|---|
| Author | Isohanni, Matti Jones, P. B. Moilanen, Kristiina Rantakallio, Paula Järvelin, M.-R. |
| Copyright Year | 2001 |
| Abstract | Delayed childhood development may precede adult psychoses. We tested this hypothesis in a large, general population birth cohort (n=12058) followed to age 31 years. The ages at which individuals learned to stand, walk, speak, and became potty-trained (bowel control) and dry (bladder control), were recorded at a 1-year examination. Psychiatric outcome was ascertained through linkage to a national hospital discharge register. Cumulative incidence of DSM-III-R schizophrenia, other psychoses and non-psychotic disorders were stratified according to the timing of milestones and compared within the cohort using internal standardization. 100 cases of DSM-III-R schizophrenia, 55 other psychoses, and 315 non-psychotic disorders were identified. The ages at learning to stand, walk and become potty-trained were each related to subsequent incidence of schizophrenia and other psychoses. Compared with the whole cohort, earlier milestones reduced, and later milestones increased, the risk in a linear manner. These developmental effects were not seen for non-psychotic outcomes. The findings support hypotheses regarding psychosis as having a developmental dimension with precursors apparent in early life. |
| Starting Page | 1 |
| Ending Page | 19 |
| Page Count | 19 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0920-9964(00)00179-1 |
| PubMed reference number | 11595387 |
| Journal | Medline |
| Volume Number | 52 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0920996400001791 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0920996400001791?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0920-9964%2800%2900179-1 |
| Journal | Schizophrenia Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
