NDLI: P338 Comparaison entre la canagliflozine et la sitagliptine chez des sujets diabétiques de type 2 sous metformine et sulfamide hypoglycémiant

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P338 Comparaison entre la canagliflozine et la sitagliptine chez des sujets diabétiques de type 2 sous metformine et sulfamide hypoglycémiant

Content Provider	Semantic Scholar
Author	Schernthaner, Guntram Groß, Jorge Yee, Jacqueline Ricci, Lanfranco Canovatchel, William Meininger, Gary
Copyright Year	2014
Abstract	Introduction La canagliflozine (CANA), un nouvel inhibiteur du co-transporteur sodium-glucose de type 2 a ete developpe pour le traitement du diabete de type 2 (DT2). Materiels et methodes Dans cette etude de phase 3, randomisee, en double aveugle, controlee versus placebo (Schernthaner G, et al. Diabetes Care. 2013 36 (9) : 2 508-2 515), des patients avec un DT2 mal controle sous metformine (MET) et sulfamide (SU) (N=755 ; âge : 56,7 ans ; HbA1C : 8,1 % ; IMC : 31,6kg/m 2 ) ont recu 300mg de CANA ou 100mg de sitagliptine (SITA) une fois par jour. Resultats A 52 semaines, CANA 300mg a montre a la fois une non-inferiorite et une superiorite vs. SITA 100mg en abaissant l'HbA1C (− 1,03 % vs. − 0,66%, respectivement). CANA a reduit le poids de maniere significative, et a ameliore la glycemie a jeun et la pression arterielle systolique vs. SITA (p Conclusion CANA a montre des ameliorations du controle glycemique et a permis de reduire le poids et la pression arterielle systolique comparativement a SITA. CANA a ete bien toleree.
File Format	PDF HTM / HTML
DOI	10.1016/S1262-3636(14)72629-1
Volume Number	40
Alternate Webpage(s)	http://www.em-consulte.com/showarticlefile/881837/main.pdf
Alternate Webpage(s)	https://www.em-consulte.com/showarticlefile/881837/main.pdf
Alternate Webpage(s)	https://doi.org/10.1016/S1262-3636%2814%2972629-1
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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