Loading...
Please wait, while we are loading the content...
Similar Documents
Effect of micropatterning induced surface hydrophobicity on drug release from electrospun cellulose acetate nanofibers
| Content Provider | Semantic Scholar |
|---|---|
| Author | Adepu, Shivakalyani Gaydhane, Mrunalini K. Kakunuri, Manohar Sharma, Chandra Shekhar Khandelwal, Mudrika Eichhorn, Stephen J. |
| Copyright Year | 2017 |
| Abstract | Abstract Sustained release and prevention of burst release for low half-life drugs like Diclofenac sodium is crucial to prevent drug related toxicity. Electrospun nanofibers have emerged recently as potential carrier materials for controlled and sustained drug release. Here, we present a facile method to prevent burst release by tuning the surface wettability through template assisted micropatterning of drug loaded electrospun cellulose acetate (CA) nanofibers. A known amount of drug (Diclofenac sodium) was first mixed with CA and then electrospun in the form of a nanofabric. This as-spun network was hydrophilic in nature. However, when electrospinning was carried out through non-conducting templates, viz nylon meshes with 50 and 100 μm size openings, two kinds of hydrophobic micro-patterned CA nanofabrics were produced. In vitro transdermal testing of our nanofibrous mats was carried out; these tests were able to show that it would be possible to create a patch for transdermal drug release. Further, our results show that with optimized micro-patterned dimensions, a zero order sustained drug release of up to 12 h may be achieved for the transdermal system when compared to non-patterned samples. This patterning caused a change in the surface wettability, to a hydrophobic surface, resulting in a controlled diffusion of the hydrophilic drug. Patterning assisted in controlling the initial burst release, which is a significant finding especially for low half-life drugs. |
| Starting Page | 755 |
| Ending Page | 762 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.apsusc.2017.07.197 |
| Volume Number | 426 |
| Alternate Webpage(s) | https://ore.exeter.ac.uk/repository/bitstream/handle/10871/29060/Revised%20Manuscript_SJEApplSurfSci.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://www.iith.ac.in/~cssharma/assets/pdf/47.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.apsusc.2017.07.197 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
