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Effects of aging on executive functioning and mesocorticolimbic dopamine markers in male Fischer 344 × brown Norway rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tomm, Ryan J. Tse, Maric T. L. Tobiansky, Daniel J. Schweitzer, Helen R. Floresco, Stan B. |
| Copyright Year | 2018 |
| Abstract | Aging is associated with changes in executive functioning and the mesocorticolimbic dopamine system. However, the effects of aging on different forms of behavioral flexibility are not fully characterized. In young (∼5 months) and aged (∼22 months) male Fischer 344 × brown Norway rats, we assessed spatial working memory and different forms of behavioral flexibility using operant tasks: strategy set-shifting (study 1) or probabilistic reversal learning (study 2). We also assessed dopaminergic markers using immunohistochemistry. Compared with young rats, aged rats displayed impairments in working memory. Aged rats also showed nonperseverative impairments in set-shifting, with a subset also showing impairments in initial discrimination learning. In probabilistic reversal learning, aged rats completed more reversals, driven by an increased sensitivity to recent reward and negative feedback. Tyrosine hydroxylase (TH) showed region-specific changes with aging and was correlated with several measures of behavioral flexibility. These data suggest that age-related changes prefrontal cortical function and dopamine synthesis contribute to changes in executive functioning during aging. |
| Starting Page | 134 |
| Ending Page | 146 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neurobiolaging.2018.08.020 |
| PubMed reference number | 30245243 |
| Journal | Medline |
| Volume Number | 72 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0197458018303117 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0197458018303117?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neurobiolaging.2018.08.020 |
| Journal | Neurobiology of Aging |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
