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Control of N‐Heterocyclic Carbene Catalyzed Reactions of Enals: Asymmetric Synthesis of Oxindole‐γ‐Amino Acid Derivatives
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chen, Xiang-Yu Xiong, Jiawen Liu, Qiang Sheng, He Essen, Carolina Von Rissanen, Kari Enders, Dieter |
| Copyright Year | 2018 |
| Abstract | A strategy to control the switchable linear and cycloaddition reactions of enals through NHC catalyisis has been developed. The new scalable protocol leads to γ-amino acid esters bearing a tetrasubstituted stereocenter in good yields and high stereoselectivities via homo-Mannich reactions of enals and isatin-derived ketimines. By simply changing the N-ketimine substituent to an ortho-hydroxy phenyl group, the corresponding spirocyclic oxindolo-γ-lactams are obtained. |
| Starting Page | 306 |
| Ending Page | 310 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/ange.201708994 |
| Volume Number | 57 |
| Alternate Webpage(s) | https://jyx.jyu.fi/bitstream/handle/123456789/58334/chenetal2018angewandtechemiemanuscript.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://doi.org/10.1002/ange.201708994 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |