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Ameliorative effect of a combination of vitamin E, vitamin C, alpha-lipoic acid and stilbene resveratrol on lindane induced toxicity in mice olfactory lobe and cerebrum.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bano, Mehajbeen Bhatt, Devendra Kumar |
| Copyright Year | 2010 |
| Abstract | Acute dose of lindane (40 mg/kg body weight, ip) caused significant reduction in butyrylcholinesterase (BChE) activity both in olfactory lobe and cerebrum of mice along with reduction in catalase (CAT), total protein and elevation in superoxide dismutase (SOD) and cholesterol contents. Pretreatment by a combination of antioxidants, vitamin E, vitamin C, a- lipoic acid and stilbene resveratrol (125 mg/kg body weight, ip) significantly augment the altered level of BChE and protect the other parameters in both the brain regions. The results were adequately in agreement with the histochemical findings, suggesting the neuroprotective efficacy of combination of antioxidants studied on the lindane induced neurotoxicity. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 20455324 |
| Journal | Medline |
| Volume Number | 48 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://nopr.niscair.res.in/bitstream/123456789/7340/1/IJEB%2048(2)%20150-158.pdf |
| Journal | Indian journal of experimental biology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |