Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers

Content Provider	Semantic Scholar
Author	Pitchot, William Wauthy, Jacques Hansenne, Michel Pinto, Emmanuel Fuchs, Sonia Reggers, Jean Legros, J. Ansseau, Marc
Copyright Year	2002
Abstract	Abstract Rationale. Flesinoxan is a highly potent and selective 5-HT1A agonist and appears to be a potentially interesting neuroendocrine serotonergic probe. Objectives. We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers. Methods. In a double-blind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times –30, 0, 15, 30, 60, 90, and 120 min. Results. Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent. Conclusions. These results showed the role of 5-HT1A mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.
Starting Page	27
Ending Page	32
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1007/s00213-002-1177-0
PubMed reference number	12373416
Journal	Medline
Volume Number	164
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/s00213-002-1177-0
Alternate Webpage(s)	https://orbi.uliege.be/bitstream/2268/195863/1/Flesi:volonteers.pdf
Alternate Webpage(s)	https://doi.org/10.1007/s00213-002-1177-0
Journal	Psychopharmacology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article