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The Association between miR-196 a 2 rs 11614913 Polymorphism and Digestive System Cancer Risk : A Meta-Analysis of 34 Studies
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhao, Rongce Zhou, Jing Liu, Fei Wei, Yonggang Chen, Kefei |
| Copyright Year | 2016 |
| Abstract | Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated metaanalysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://file.scirp.org/pdf/OJIM_2016113010500492.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cancer of Digestive System Carcinogenesis Cochrane Library Colorectal Carcinoma Confidence Intervals Congenital neurologic anomalies Database Embase Gastrointestinal system Gene Expression Genetic Polymorphism Human-centered computing Large Liver carcinoma MIR196A2 gene Meta Analysis (statistical procedure) MicroRNAs Natural Science Disciplines Neoplasms Nitroprusside Nucleotides Odds Ratio Oncogenes Population PubMed Single Nucleotide Polymorphism Stata Stomach Carcinoma Subgroup A Nepoviruses Tumor Suppressor Genes |
| Content Type | Text |
| Resource Type | Article |
