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Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3 , 4-dehydroxanthomegnin
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kitagawa, Rodrigo Rezende Vilegas, Wagner Zeppone, Iracilda C. Carlos Raddi, Maria Stella Gonçalves |
| Copyright Year | 2011 |
| Abstract | Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 μM and 74.6±1.9 μM, respectively). These results indicate that the 5-methoxy-3,4dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.scielo.br/pdf/rbfar/2011nahead/aop13211.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 1,2-naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin Antifungal Agents Antimalarials Carcinoma of lung Lightweight Portable Security Mammary Neoplasms Naphthoquinones Nitric Oxide Quinones |
| Content Type | Text |
| Resource Type | Article |
