NDLI: CD8(+) T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis.

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CD8(+) T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis.

Content Provider	Semantic Scholar
Author	Fiorillo, M. T. Maragno, M. Butler, Rachel K. Dupuis, Maria Luisa Sorrentino, Rosa
Copyright Year	2000
Abstract	HLA-B27 is highly associated with ankylosing spondylitis (AS), but the mechanism is unknown. Among the HLA-B27 alleles, B2709, which differs by one amino acid from the susceptible B2705, is not associated with the disease. Here, we analyze the reactivity, in patients with AS and in healthy controls carrying the B2709 or B2705 alleles, to an EBV epitope derived from LMP2 (236-244) and to a sequence-related self-peptide from vasoactive intestinal peptide receptor 1 (VIP1R 400-408). We found that both B2705(+) and B2709(+) subjects possess LMP2 236-244-specific, HLA-B27-restricted T cells, whereas only the B2705(+) individuals respond significantly to VIP1R 400-408. These results prompted us to compare, by IFN-gamma ELISPOT analysis, the T-cell response to VIP1R 400-408 in patients with AS versus B2705 healthy controls. The data show that VIP1R 400-408-specific reactivity is a major feature of the patients with AS. These findings show, for the first time to our knowledge, a widespread reactivity in patients with AS against a self-epitope that exhibits some features of a putative "arthritogenic" peptide.
Starting Page	47
Ending Page	53
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/9000/9295/JCI0009295.pdf
PubMed reference number	10880047v1
Volume Number	106
Issue Number	1
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	Alleles Amino Acids Ankylosing spondylitis Cellular Phone Enzyme-Linked Immunospot Assay Epstein-Barr Virus Exhibits as Topic HLA Antigens HLA-B27 Antigen Histocompatibility Antigens Class II Interferon Type II PSMB9 gene Patients Peptide Receptor Receptors, Vasoactive Intestinal Peptide T-Lymphocyte VIPR1 protein, human
Content Type	Text
Resource Type	Article

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