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Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

Content Provider	Semantic Scholar
Author	Mora-Bermúdez, Felipe Badsha, Farhath Kanton, Sabina Camp, J. Gray Vernot, Benjamin Koehler, Kathrin Susan Voigt, Birger Okita, Keisuke Maricic, Tomislav He, Zhisong Lachmann, Robert Pääbo, Svante Treutlein, Barbara Huttner, Wieland B.
Copyright Year	2016
Abstract	Human neocortex expansion likely contributed to the remarkable cognitive abilities of humans. This expansion is thought to primarily reflect differences in proliferation versus differentiation of neural progenitors during cortical development. Here, we have searched for such differences by analysing cerebral organoids from human and chimpanzees using immunohistofluorescence, live imaging, and single-cell transcriptomics. We find that the cytoarchitecture, cell type composition, and neurogenic gene expression programs of humans and chimpanzees are remarkably similar. Notably, however, live imaging of apical progenitor mitosis uncovered a lengthening of prometaphase-metaphase in humans compared to chimpanzees that is specific to proliferating progenitors and not observed in non-neural cells. Consistent with this, the small set of genes more highly expressed in human apical progenitors points to increased proliferative capacity, and the proportion of neurogenic basal progenitors is lower in humans. These subtle differences in cortical progenitors between humans and chimpanzees may have consequences for human neocortex evolution.
Starting Page	166
Ending Page	169
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTg2ODMvZWxpZmUtMTg2ODMtdjMucGRm/elife-18683-v3.pdf?_hash=6WKMJ9a1lSEwwIJlDfmkAdzw1zoPjoRtQSwpq3vHPRk%3D
Alternate Webpage(s)	https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTg2ODMvZWxpZmUtMTg2ODMtZmlndXJlcy12My5wZGY=/elife-18683-figures-v3.pdf?_hash=L4SWqcRD6nvyIhVClg/5ixAGJXL%2BaotbOVbQTY%2BZhRc%3D
PubMed reference number	27669147
Alternate Webpage(s)	https://doi.org/10.7554/eLife.18683
DOI	10.7554/elife.18683
Journal	eLife
Volume Number	5
Language	English
Access Restriction	Open
Subject Keyword	Basal Ganglia Diseases Cerebral cortex Gene Expression Homo sapiens Mitosis Mitotic Metaphase Neocortex Organoids Pan troglodytes Prometaphase Search - action
Content Type	Text
Resource Type	Article

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Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

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Data from: Y-chromosome structural diversity in the bonobo and chimpanzee lineages (Dataset)

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