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Antibacterial activity of medicinal plants against multidrug-resistant bacteria.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Saraiva, Rosa Maria Borges, E. Da S. Ferreira, Fabienne Antunes Brandão, Diego N. Vieira, Antônia Benedita Rodrigues Vieira, José Maria Dos Santos |
| Copyright Year | 2012 |
| Abstract | The main cause of increasing of infectious diseases cases is due to multidrugresistant microorganisms emergence, particularly Pseudomonas aeruginosa and Staphylococcus aureus, responsible for most of hospital-acquired infections and millions deaths related. Despite development of new antibiotics, control of these microorganisms is not always successful. Several plant extracts have demonstrated antimicrobial effects and may be used as an alternative therapy for these infections. Aiming to evaluate antibacterial activity of extracts from Eleutherine plicata (marupazinho), Geissospermum vellosii (pau-pereira) and Portulaca pilosa (amor crescido) against multidrugresistant bacteria, samples of Oxacillin-Resistant Staphylococcus aureus (ORSA) and multidrug-resistant P. aeruginosa (MDR P. aeruginosa) isolated from human clinical processes were tested. The antibacterial activity was determined by disk diffusion method and minimum inhibitory concentration (MIC) by microdilution method. Extracts and fractions were tested at concentrations of 500, 250, 125, 62.5, 31.2 and 16.2 μg/mL dissolved in DMSO 10%. E. plicata and G. vellossi have shown activity against ORSA at MIC of 125 μg/L, whilst P. pilosa have shown action on MDR P. aeruginosa at MIC of 250 μg/mL. Results suggest the extracts of E. plicata, G. velossi and P. pilosa have antimicrobial activity with potential use as phytoterapic drugs or for further research on new antimicrobial drugs. INTRODUCTION: Medicinal plants have been used in treatment of diseases as a common strategy virtually by all populations around the world. In Brazil it is common in the poorest regions as well as in big cities, to find medicinal plants in free markets, supermarkets and even in backyards of houses . In Brazil, over 55 thousand plants species have been described, about 20% of plants on the planet, the largest biodiversity in the world. There is a well stablished acceptance of medicinal plants use associated to traditional knowledge . Infectious diseases affect millions of people around the world and they are one of the main causes of death in History. This problem is exacerbated by emergence of multidrug-resistant microorganisms, especially Staphylococcus aureus and Pseudomonas aeruginosa, present in hospital and community acquired infections, decreasing antibiotic therapy options 3, . Due to increasing of resistance against several antimicrobial drugs, searching for new therapeutic alternatives using medicinal plants play an important role for obtaining new drugs. |
| Starting Page | 4841 |
| Ending Page | 4847 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Volume Number | 3 |
| Alternate Webpage(s) | http://www.ijpsr.com/V3I12/39%20Vol.%203,%20Issue%2012,%20December%202012,%20IJPSR,%20RA%201932,%20Paper%2039.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
