NDLI: Quantification of intrapulmonary blood shunt and ventilation/perfusion distributions in injured lungs by positron emission tomography

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Quantification of intrapulmonary blood shunt and ventilation/perfusion distributions in injured lungs by positron emission tomography

Content Provider	Semantic Scholar
Author	Seow, Desmond
Copyright Year	1995
Abstract	The ability to determine the condition of injured lungs is crucial in pulmonary medicine. Although current available methodologies are able to aid in these decisions, most are invasive in nature, time consuming, and cannot be combined on the same patient for simultaneous measurements of all the variables relevant to pulmonary function. With appropriate physiological models, Positron Emission Tomography ( PET ) provides a unique opportunity to noninvasively and accurately quantify the required variables needed to obtain an unbiased view of the injured lung condition. This thesis deals with novel methodologies to produce and analyze PET images of perfusion (0), alveoli ventilation (VA), VA /Q ratio, and intrapulmonary blood shunt on the same subject non-invasively. These methodologies represent a significant advancement over existing procedures in the topographic determination of injured lung condition. The methodologies and models were implemented in studies to accurately determine lung function of unilaterally transplanted pig lungs, the ventilator condition of a lung with a stenosed bronchus under high frequency jet ventilation using air and a helium-oxygen gas mixture, and the gas exchange condition of a surfactant depleted dog lung. After validation and minor changes to the experimental protocols, these methodologies with PET can be used as clinical diagnostic tools. Thesis Supervisor: Jose G. Venegas Title: Assistant Professor, Harvard Medical School Quantification of Intrapulmonary Blood Shunt and Ventilation / Perfusion Distributions in Injured Lungs by Positron Emission Tomograpy
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dspace.mit.edu/bitstream/handle/1721.1/37553/34317181-MIT.pdf?sequence=2
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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