Evaluation of Insulin Potentiating Activity of Ethanolic Root Extract of Boerhavia Diffusa in Streptozotocin -Induced Diabetic Rats

Content Provider	Semantic Scholar
Author	Kumar, G. Anvesh Srikanth, Sharadha Chidrawar, Vijay R. Rao, Uma Maheswara
Copyright Year	2013
Abstract	To evaluate anti-diabetic activity, insulin potentiating activity of ethanolic root extract of Boerhavia diffusa (BD) in streptozotocin induced diabetic rats and isolation of active fraction from the extract. The ethanolic root extract was tested for its Acute toxicity studies and insulin potentiating activity and the dosages were selected as 200mg & 300mg /kg body weight for the activity screening. Glibenclamide 0.5 mg/Kg body wt. was used as standard and Insulin 10 units/Kg body wt. was used concurrently with the extracts for 14 days. At 0, 5, 10, 15 day fasting blood glucose level measured and 15 th day serum lipid levels and pancreas histopathology were observed. Ethanolic extract (300mg/kg) p.o with insulin treated group exhibited significant anti hyperglycemic activity in streptozotocin induced diabetic rats. It also improved the condition of diabetes parameters like body weight gain, serum cholesterol, triglycerides, HDL, LDL and VLDL when compared with the diabetic control group. Butanol fraction showed significant decrease in blood glucose levels compared with the other fractions of BD. Histopathological studies indicated that there is dose dependent effect of the BD extract on the preservation of architecture of pancreatic cells. The results indicated that the Boerhavia diffusa possesses antidiabetic and insulin potentiating activity.
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Resource Type	Article