Fixation of Light Weight Polypropylene Mesh with n-Butyl-2-cyanocrylate in Pelvic Floor Surgery: Experimental Design Approach in Sheep for Effectiveness Evaluation

Content Provider	Semantic Scholar
Author	Barbosa, Sandra Carla Pereira Nieves, Tania García, F. Cepeda, Eva Moll, Xavier García Marco, Alberto Weis, Christine Turon, Pau Vergara, Patri
Copyright Year	2015
Abstract	OBJECTIVE The aim of this study was to find a proper experimental design and to evaluate n-butyl-2-cyanoacrylate (Histoacryl) as a fixation method for a light-weight and large pore PP mesh (Synthetic PP Mesh-1) using the sheep as an animal model. METHODS Posterior vaginal implantation by means of episiotomy was used to implant 8 ewes which were evaluated macroscopically and histologically at 3 months (n = 4) and 6 months (n = 4) post-surgery. In previous pilot studies anterior vaginal implantation was evaluated, as well as different synthetic mesh materials, sizes and fixation methods (n = 1 to 3) during three weeks. In all cases a clinical evaluation of the animal was performed. RESULTS A reduction in the mesh size (Synthetic PP Mesh-1) together with precise application of the surgical glue Histoacryl to fix the mesh yielded significantly better histocompatibility results (P < 0.01) compared to larger size or other fixation methods. CONCLUSION The combination of Synthetic PP Mesh-1 with Histoacryl offered a high degree of graft integration without vaginal ulceration and a minimal foreign body reaction, being the sheep a proper animal model to test these types of medical devices.
File Format	PDF HTM / HTML
DOI	10.1155/2015/737683
PubMed reference number	26221605
Journal	Medline
Volume Number	2015
Alternate Webpage(s)	http://downloads.hindawi.com/journals/bmri/2015/737683.pdf
Alternate Webpage(s)	https://doi.org/10.1155/2015%2F737683
Journal	BioMed research international
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article