NDLI: Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds.

Content Provider	Semantic Scholar
Author	Qian, Yu-Lun Xia, Peng-Ju Zhao, Qing-Lan Xiao, Jun-An Xiang, Hao-Yue Yang, Hua
Copyright Year	2017
Abstract	A diversity-driven three-component 1,3-dipolar cycloaddition of isatins, amino acids and isatin-derived ketimines was developed to facilely assemble dispirooxindole-imidazolidine skeletons bearing vicinal quaternary carbon centers. This protocol features additive-free, minimal solvent usage (0.1 mL DMSO/0.2 mmol scale), wide substrate scope (34 examples), mild reaction conditions (room temperature) and high chemical yield (up to 99%).
Starting Page	8705
Ending Page	8708
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1039/c7ob02319g
Alternate Webpage(s)	http://www.rsc.org/suppdata/c7/ob/c7ob02319g/c7ob02319g1.pdf
PubMed reference number	29022628
Alternate Webpage(s)	https://doi.org/10.1039/c7ob02319g
Journal	Medline
Volume Number	15
Issue Number	41
Journal	Organic & biomolecular chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds.