NDLI: Fluorescent DNA probes: Study of mechanisms of changes in spectral properties and features of practical application

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Fluorescent DNA probes: Study of mechanisms of changes in spectral properties and features of practical application

Content Provider	Semantic Scholar
Author	Sibirtsev, V. S.
Copyright Year	2007
Abstract	Spectral data and nucleic acid complex formation properties for more than 30 both newly synthesized and widely used fluorescent nucleotide-specific compounds of various classes have been analyzed. These include phenylbenzene, bisbenzimidazole, psoralen, angelicin, tetrahydrocarbazole, oxophenoxazine, and others. The main rules of a generalized model adequately explaining changes in fluorescent properties of synthetic, low molecular weight nucleotide-specific dyes depending on their chemical structure, mode of interaction with substrate, properties of assay medium, etc. are proposed. Fluorescent nucleotide-specific dyes have been originally used in newly developed methods for: express evaluation of “generalized microbial dissemination” of liquid media; evaluation of possible genotoxic effects of various foodstuffs, pharma-ceutical drugs, hazardous environmental factors (including their combined effects on living organisms), etc.
Starting Page	887
Ending Page	900
Page Count	14
File Format	PDF HTM / HTML
DOI	10.1134/S0006297907080111
Alternate Webpage(s)	http://vs1969r.narod.ru/Publ/Stat27-e.pdf
PubMed reference number	17922647
Alternate Webpage(s)	https://doi.org/10.1134/S0006297907080111
Journal	Medline
Volume Number	72
Journal	Biochemistry (Moscow)
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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