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Nitrates he Pros and Cons of itric Oxide Replacement Therapy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gori, Ommaso Parker, Ohn D. |
| Copyright Year | 2016 |
| Abstract | rganic nitrates are among the oldest and most commonly sed drugs for the treatment of cardiovascular disease. In the hort term, nitrates have a rapid onset of action, lowering lood pressure and cardiac filling pressures, and they are sed to treat episodes of angina for short-term control of lood pressure and in the treatment of pulmonary congesion. Despite the wide clinical use of these drugs and a large ody of research in this field, it is interesting to note that 60 years after Ascanio Sobrero first synthesized nitroglycrin, we remain with three questions of fundamental imortance: 1) How do nitrates work? 2) Why do nitrates stop orking upon continuous administration? and 3) What are he long-term effects of nitrate therapy on clinical outcome? nterestingly, these questions appear to be closely interrelated. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.onlinejacc.org/content/accj/44/3/632.full.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
