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Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch
| Content Provider | Semantic Scholar |
|---|---|
| Author | Li, Zhongjie Hu, Ping Wu, Wenlan Wang, Yong |
| Copyright Year | 2019 |
| Abstract | HighlightsVenom of the scorpion Buthus martensii Karsch constitutes a vast array of biologically active peptides.Several of the peptides possess anticancer, antibacterial, antiepileptic, and analgesic activities.These peptides with therapeutic potential are attractive candidates for drug development. ABSTRACT The scorpion Buthus martensii Karsch (BmK) has generated significant interest due to the presence of biologically active peptides in its venom. In the past decade, dozens of different peptides from BmK have been identified. Most of the peptides are neurotoxins and are responsible for the toxicity of BmK venom. Other peptides, including neurotoxins and non‐disulfide‐bridged peptides, show potential anticancer, antimicrobial, analgesic, and anti‐epileptic therapeutic effects. These peptides are attractive candidates for drug development, and peptide derivatives have also been designed to enhance their therapeutic potential, such as ADWX‐1 and Kn2‐7. In this review, we provide an overview of the most promising peptides found in BmK venom and of modified peptide derivatives showing therapeutic potential. |
| Starting Page | 43 |
| Ending Page | 50 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.peptides.2019.02.009 |
| PubMed reference number | 30858089 |
| Journal | Medline |
| Volume Number | 115 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0196978119300257 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0196978119300257?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.peptides.2019.02.009 |
| Journal | Peptides |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
