NDLI: Escherichia coli pathotypes associated with diarrhea in a Coastal Ecuadorian city

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Escherichia coli pathotypes associated with diarrhea in a Coastal Ecuadorian city

Content Provider	Semantic Scholar
Author	Llerena, Páez Gardenia, Maritza
Copyright Year	2016
Abstract	Diarrhea is the second leading cause of death among children under five years old around the world and diarrheagenic Escherichia coli (DEC) is one of the causes of this disease in developing countries like Ecuador. Diagnosis of E. coli pathotypes and knowledge of antibiotic resistance profiles are necessary to control the disease. The present study analyzed DEC in 223 stool samples, collected from Esmeraldas hospital Delfina Torres de Concha from April to September 2014. The diagnosis was made by conventional PCR using specific primers for each pathotype and 12 antibiotics were used to determine the antibiotic resistance profile with disk diffusion method. The prevalence of DEC was 46.84% in cases of diarrhea and 28.57% in controls, and a statistically significant association with diarrhea (Odds Ratio (OR) =2.20, 95% CI: 1.22-3.98, P=0.004). The most prevalent pathotype in cases and controls was Diffuse Adherent E. coli (DAEC) with 26.12% in cases and 12.5% in controls and a statistically significant association with diarrhea (OR=2.47, 95% CI: 1.16-5.40 P=0.009). DEC co-infections were found in 6.30% cases and 4.46% controls; this difference was not statistically significant (OR = 1.44, 95% CI: 0.37-5.93, P=0.542). Finally, pathotypes exhibited clinical resistance to 11 of 12 antibiotics analyzed, sulfisoxazole (79.76%), followed by ampicillin (76.19%), sulfamethoxazole-trimethoprim (73.80%), streptomycin and tetracycline (61.90%), cephalotin (48.80%), chloramphenicol (17.85%), amoxicillin-clavulanic acid (9.52%), gentamicin (8.33%), cefotaxime (7.14%) and ciprofloxacin (5.95%). No resistance was observed to imipenem.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://repositorio.usfq.edu.ec/bitstream/23000/6182/1/127708.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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