NDLI: Xanthoceraside prevented synaptic loss and reversed learning-memory deficits in APP/PS1 transgenic mice

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Xanthoceraside prevented synaptic loss and reversed learning-memory deficits in APP/PS1 transgenic mice

Content Provider	Semantic Scholar
Author	Liu, Peng Xu, Qian Qian Zhou, Xiaoyu Xu, Ji-Kai Ji, Xuefei Chi, Tianyan Zou, Libo
Copyright Year	2019
Abstract	Xanthoceraside, a novel triterpenoid saponin, has been found to attenuate learning and memory impairments in AD animal models. However, whether xanthoceraside has a positive effect on synaptic morphology remains unclear. Herein, we evaluated the effects of xanthoceraside on learning and memory impairments and the abnormalities of synaptic structure in APP/PS1 transgenic mice. The behavioral experiments demonstrated that xanthoceraside attenuated the imaginal memory and spatial learning impairments, and improved social interaction. Transmission electron microscopy and Golgi staining showed that xanthoceraside ameliorated synapse morphology abnormalities and dendritic spine density deficits, respectively. Western-blot analysis identified that xanthoceraside increased the expression of SYP and PSD95, activated BDNF/TrkB/MAPK/ERK and PI3K/Akt signaling pathways, meanwhile decreased the expression of RhoA, ROCK and Snk, increased the levels of SPAR, and activated the BDNF/TrkB/cofilin signaling pathway. Taken together, our study indicated that xanthoceraside improved cognitive function and protected both synaptic morphology and dendritic spine in APP/PS1 transgenic mice, which might be related in part to its activation in the BDNF/TrkB pathway.
Starting Page	477
Ending Page	488
Page Count	12
File Format	PDF HTM / HTML
DOI	10.1007/s12576-019-00664-x
Alternate Webpage(s)	https://jps.biomedcentral.com/track/pdf/10.1007/s12576-019-00664-x
PubMed reference number	30767122
Alternate Webpage(s)	https://doi.org/10.1007/s12576-019-00664-x
Journal	Medline
Volume Number	69
Journal	The Journal of Physiological Sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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